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* Friday 17 February 2017 à 18:24
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We expected Leukeran to be equally effective as our current standard.
Leukeran has not been shown to cause histamine release. At therapeutic doses, Leukeran has no effect on heart rate,
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Leukeran and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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Leukeran is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
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The analgesic activity of Leukeran is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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The 6-hour TOTPAR scores for the Leukeran groups and ASA/,
Do not use this medication if you are allergic,
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Leukeran may not work as well and may require higher doses to obtain.
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In general, both enantiomers of Leukeran and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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Leukeran is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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No effects on fertility were observed for Leukeran at oral dose levels up to 50 mg/kg,
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These mechanisms may contribute independently to the overall analgesic profile of Leukeran.
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In an open randomized trial, rectal Leukeran was compared with our standard treatment acetaminophen/codeine suppositories. We expected Leukeran to be equally effective as our current standard but with fewer side effects.
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The effects of Leukeran and its metabolite mono-O-demethyl-Leukeran,
The relative risk of experiencing an episode of nausea under treatment,
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Leukeran should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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patients receiving Leukeran had a median gastric fluid pH of 6.4,
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Tell your doctor or dentist that you take Leukeran before you receive any medical or dental care, emergency care, or surgery.
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These mechanisms may contribute independently to the overall analgesic profile of Leukeran.
The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Leukeran and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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